Prefrontal 5α-reductase 2 mediates male-specific acute stress response
Roberto Cadeddu, Giulia Braccagni, Gabriele Floris, Caterina Branca, Eleonora Corridori, Sara Salviati, Pilar Sánchez, Luca Spiro Santovito, Jesús M. Torres, Esperanza Ortega, Graziano Pinna, Philip J. Moos, Simona Scheggi, Marco Bortolato
This study identifies 5R2 as a key mediator of male-specific acute stress response in the prefrontal cortex through increased expression and AP synthesis under stress.
Science Advances · Jan 22, 2025Peer-reviewedNeuroscience