Author

Simona Scheggi

University of SienaORCID 0000-0002-0229-6090Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Animal Behavior & Cognition· 1

Signature Assays, Organisms & Methods

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Organism:rat· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Assay:electrophysiology· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Marco BortolatoiD· 3 shared Caterina BrancaiD· 2 shared Eleonora CorridoriiD· 2 shared Gian Michele RattoiD· 2 shared Giulia BraccagniiD· 2 shared Roberto CadedduiD· 2 shared Sara SalviatiiD· 2 shared Esperanza Ortega· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersNeuroscience

Marco BortolatoORCID

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3 papers

Recent·Most cited

Sleep deprivation impairs information processing via dysregulation of chloride homeostasis in the prefrontal cortex

Roberto Frau, Luca Concas, Giulia Braccagni, Francesco Traccis, Caterina Branca, Sara Salviati, Valeria Serra, Eleonora Corridori, Gabriele Nardi, Giacomo Pasquini, Silvia Landi, Michele Santoni, Paolo Follesa, Federico Brandalise, Monica Puligheddu, , Marco Bortolato

This study shows sleep deprivation impairs information processing in the prefrontal cortex by disrupting chloride homeostasis through KCC2 reduction and BDNF-TrkB signaling, which can be mitigated by bumetanide or AP synthesis blockade.

bioRxiv · Mar 18, 2026 · PreprintAnimal Behavior & Cognition

Prefrontal 5α-reductase 2 mediates male-specific acute stress response

Roberto Cadeddu, Giulia Braccagni, Gabriele Floris, Caterina Branca, Eleonora Corridori, Sara Salviati, Pilar Sánchez, Luca Spiro Santovito, Jesús M. Torres, Esperanza Ortega, Graziano Pinna, Philip J. Moos, Simona Scheggi, Marco Bortolato

This study identifies 5R2 as a key mediator of male-specific acute stress response in the prefrontal cortex through increased expression and AP synthesis under stress.

Science Advances · Jan 22, 2025Peer-reviewedNeuroscience

Acute stress impairs sensorimotor gating via the neurosteroid allopregnanolone in the prefrontal cortex

Roberto Cadeddu, Laura J. Mosher, Peter Nordkild, Nilesh W. Gaikwad, Gian Michele Ratto, Simona Scheggi, Marco Bortolato

This study shows acute stress impairs sensorimotor gating by increasing allopregnanolone in the prefrontal cortex, which can be reversed by blocking allopregnanolone.

Neurobiology of Stress · Sep 24, 2022Peer-reviewedNeuroscience