Philip J. Moos

DS5 is an open-source framework that standardizes HTS data storage, analysis, and drug prioritization, validated against public benchmarks and applied in clinical settings.

This study identifies pervasive transcriptional remodeling in the dorsolateral prefrontal cortex of individuals with Tourette disorder, highlighting stress-related gene activation in multiple cell types.

The paper detects Mtb transcripts in human granuloma cells using scRNA-seq, finding sequence variations suggesting potential adaptive mechanisms.

This study uses scRNA-seq and WGS to analyze HSCR patient tissues, identifying impaired neuronal differentiation in aganglionic colon segments.

This study uses long-read scRNA-seq to analyze cancer subclone-specific mutations and transcriptomic differences in CLL patients with BTKC481S mutations.

This study identifies 5R2 as a key mediator of male-specific acute stress response in the prefrontal cortex through increased expression and AP synthesis under stress.

This study uses scRNA-seq to analyze granulomatous lymph nodes from TB patients, identifying cell types, signaling networks, and Mtb RNA detection in infected cells.

The paper investigates how Celsr3 mutations affect tic-like behaviors in mice by examining striatal dopamine receptor alterations.

The paper shows that combining ribociclib and adavosertib reduces growth of mixed cancer cell cultures and limits resistance development.