Giulia Braccagni

This study identifies pervasive transcriptional remodeling in the dorsolateral prefrontal cortex of individuals with Tourette disorder, highlighting stress-related gene activation in multiple cell types.

This study shows sleep deprivation impairs information processing in the prefrontal cortex by disrupting chloride homeostasis through KCC2 reduction and BDNF-TrkB signaling, which can be mitigated by bumetanide or AP synthesis blockade.

This study shows that elevated prefrontal 5-HT2A receptors contribute to tic development in TS and that pimavanserin reduces tic-like behaviors and aggression in mouse models.

This study identifies 5R2 as a key mediator of male-specific acute stress response in the prefrontal cortex through increased expression and AP synthesis under stress.

The paper investigates how Celsr3 mutations affect tic-like behaviors in mice by examining striatal dopamine receptor alterations.