Identification of chemotherapy targets reveals a nucleus-to-mitochondria ROS sensing pathway
Junbing Zhang, Claire M. Simpson, Jacqueline Berner, Harrison Byron Chong, Jiafeng Fang, Zehra Ordulu, Tommy Weiss‐Sadan, Anthony P. Possemato, Stefan Andrew Harry, Mariko Takahashi, Tzu-yi Yang, Marianne Richter, Himani Patel, Abby E. Smith, Alexander Daniel Carlin, , Liron Bar‐Peled
The paper identifies a nucleus-to-mitochondria ROS sensing pathway involving CHK1 and SSBP1 that mediates resistance to platinum-based chemotherapies in ovarian cancers.
bioRxiv · Mar 11, 2023 · PreprintMolecular Biology