Author

Bo R. Rueda

Harvard UniversityORCID 0000-0001-9489-8699Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Assay:proteomics· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:organoid / primary culture· 1 Approach:statistical model· 1

Frequent Co-Authors

Venkatesh PooladandaiD· 3 shared Eugene KimiD· 2 shared Kristopher A. SarosiekiD· 2 shared Shaan KumariD· 2 shared Xingping QiniD· 2 shared Yusuke MatobaiD· 2 shared Abby E. Smith· 1 shared Adam G. PresseriD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCancer Biology

Venkatesh PooladandaORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Extracellular vesicles facilitate the horizontal transfer of drug resistance and stem-like properties between ovarian tumor cells

Venkatesh Pooladanda, Rui Fang Xu, Dominique T. Zarrella, Yusuke Matoba, Chisa Shimada, Shaan Kumar, Eugene Kim, Paula J DiBenedetto, Xingping Qin, Kristopher A. Sarosiek, Madelyn Krueger, Narela Magrassi, Mansoor M. Amiji, Maryam Azimi Mohammadabadi, Ursula Winter, , Bo R. Rueda

This study shows that extracellular vesicles from ovarian cancer stem cells or drug-resistant cells transfer stem-like properties and drug resistance to sensitive cells via EZH2 signaling.

bioRxiv · Jan 23, 2026 · PreprintCancer Biology

Extracellular vesicles regulate metastable phenotypes of lymphangioleiomyomatosis cells via shuttling ATP synthesis to pseudopodia and activation of integrin adhesion complexes.

Anil Kumar Kalvala, Ashok Silwal, Bhaumik B. Patel, Apoorva Kasetti, Kirti Rajendra Shetty, Jan Markiewski, Jun‐Hung Cho, Gerard Lara, Elizabeth A. Daugherity, Rémi Diesler, Venkatesh Pooladanda, Bo R. Rueda, Elizabeth P. Henske, Jane J. Yu, Maciej M. Markiewski, Magdalena Karbowniczek

This study shows that extracellular vesicles from LAM cells promote metastasis by delivering ATP to pseudopodia and activating integrin adhesion complexes.

Communications Biology · Nov 20, 2025Peer-reviewedCancer Biology

Paclitaxel-induced mitotic arrest results in a convergence of apoptotic dependencies that can be safely exploited by BCL-XL degradation to overcome cancer chemoresistance

Xingping Qin, Adam G. Presser, Lissah Johnson, Yusuke Matoba, Brendan Shay, Weiyi Xu, Jonathan Choiniere, Cameron Fraser, Filip Garbicz, Johan K. E. Spetz, Stacey J. Yu, Mary H.C. Florido, Francesca Picucci, Yang Yang, Ronny Drapkin, , Kristopher A. Sarosiek

bioRxiv · Jun 24, 2025 · PreprintCancer Biology

Identification of chemotherapy targets reveals a nucleus-to-mitochondria ROS sensing pathway

Junbing Zhang, Claire M. Simpson, Jacqueline Berner, Harrison Byron Chong, Jiafeng Fang, Zehra Ordulu, Tommy Weiss‐Sadan, Anthony P. Possemato, Stefan Andrew Harry, Mariko Takahashi, Tzu-yi Yang, Marianne Richter, Himani Patel, Abby E. Smith, Alexander Daniel Carlin, , Liron Bar‐Peled

The paper identifies a nucleus-to-mitochondria ROS sensing pathway involving CHK1 and SSBP1 that mediates resistance to platinum-based chemotherapies in ovarian cancers.

bioRxiv · Mar 11, 2023 · PreprintMolecular Biology