Claire M. Simpson

Brain shuttle target expression levels vary by individual, not by brain region, disease, age, or sex

The paper shows brain shuttle target expression varies between individuals but not by brain region, disease, age, or sex.

Cell signaling pathways discovery from multi-modal data

The paper introduces Incytr, a method for discovering cell signaling pathways from multi-omics data, demonstrating its application in disease contexts and showing its utility for drug discovery and understanding cell communication.

Lifting the curse from high dimensional data: Automated projection pursuit clustering for the variety of biological data modalities

The paper introduces APP, a clustering method that reduces high-dimensional biological data to lower dimensions to improve clustering performance across multiple data types.

Identification of chemotherapy targets reveals a nucleus-to-mitochondria ROS sensing pathway

The paper identifies a nucleus-to-mitochondria ROS sensing pathway involving CHK1 and SSBP1 that mediates resistance to platinum-based chemotherapies in ovarian cancers.

Characterization and Preclinical Treatment of Rotational Force-Induced Brain Injury

This study develops a rodent model of rotational head trauma, identifies Cdk5 as a key mediator, and shows its inhibition reduces cognitive and pathological effects.