Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies
Ethan G. Stoddard, B. Gayani K. Perera, Linglan Fang, Daniel S Brush, Yuhao Zhong, Zachary E. Potter, Jessica J. Simon, Martin G. Golkowski, Dustin J. Maly
This study identifies how Raf inhibitor potency varies with Raf activity and shows that cobimetinib enhances sensitivity to DFG-out inhibitors by disrupting autoinhibited Raf-Mek complexes.
Nature Chemical Biology · May 12, 2026Peer-reviewedCell Biology