Martin G. Golkowski

This study identifies a kinase network and DAPK3-driven polarity complex that promotes HCC cell migration and metastasis using a multi-modal profiling approach.

This study identifies how Raf inhibitor potency varies with Raf activity and shows that cobimetinib enhances sensitivity to DFG-out inhibitors by disrupting autoinhibited Raf-Mek complexes.

This study identifies PERM1 as a downstream target of PRDM16 and shows that Perm1 gene therapy improves cardiomyopathy in Prdm16 knockout mice through mitochondrial and sarcomere preservation.

This study identifies NUAK1 as a critical host factor for Plasmodium falciparum infection and shows that NUAK1 inhibitors block parasite growth.

This paper introduces an improved chemoproteomics method for mapping kinase PPI networks, showing it identifies more interactions and predicts drug targets in neuroblastoma models.

The paper shows that mutations in PKAc cause displacement from AKAP signaling islands, leading to distinct pathogenic signaling pathways in Cushing's syndrome.