Cell type-centric interaction networks define spatial architecture of intrahepatic cholangiocarcinoma
Hsin-Pei Lee, Meng Liu, Wenqi Wu, Ngoc Thao Lam Nguyen, Jittiporn Chaisaingmongkol, Darko Castven, Ethan Levy, Noémi Kedei, Maria Olga Hernandez, Manjari Kundu, Marshonna Forgues, Man‐Hsin Hung, Anuradha Budhu, Nada Alani, Stephen M. Hewitt, , Lichun Ma
This study defines the spatial architecture of intrahepatic cholangiocarcinoma using single-cell spatial proteomics and a graph-based deep learning framework to identify multicellular spatial patterns and their association with patient outcomes.
bioRxiv · Jun 6, 2026 · PreprintCancer Biology