Author

Lichun Ma

National Cancer InstituteORCID 0000-0001-9809-775XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:deep learning· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Research Focus:spatial domain detection· 2 Assay:spatial transcriptomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Meng LiuiD· 3 shared Darko CastveniD· 2 shared Hsin-Pei Lee· 2 shared Jens Uwe MarquardtiD· 2 shared Maria Olga HernandeziD· 2 shared Marshonna ForguesiD· 2 shared Wenqi WuiD· 2 shared Allan M. JohanseniD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCancer Biology

Meng LiuORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Tumor-specific Kinase Motif Enrichment Analysis Identifies Personalized Therapeutic Cancer Targets

Tracey Pu, Brian A. Joughin, Priyanka Prakash Desai, Steven Donald Forsythe, Ronald J. Holewinski, Kirsten Remmert, Billel Gasmi, Kendra Coleman, Timothy Leach, Allan M. Johansen, Nicole Russell, Lichun Ma, Ashley J. Rainey, Amber Leila Sarvestani, Emily Smith, , Jonathan Matthew Hernandez

The paper uses phosphoproteomic data and KMEA to identify tumor-specific kinase activity in GEP-NETs, revealing potential therapeutic targets.

bioRxiv · Aug 9, 2026 · PreprintCancer Biology

Cell type-centric interaction networks define spatial architecture of intrahepatic cholangiocarcinoma

Hsin-Pei Lee, Meng Liu, Wenqi Wu, Ngoc Thao Lam Nguyen, Jittiporn Chaisaingmongkol, Darko Castven, Ethan Levy, Noémi Kedei, Maria Olga Hernandez, Manjari Kundu, Marshonna Forgues, Man‐Hsin Hung, Anuradha Budhu, Nada Alani, Stephen M. Hewitt, , Lichun Ma

This study defines the spatial architecture of intrahepatic cholangiocarcinoma using single-cell spatial proteomics and a graph-based deep learning framework to identify multicellular spatial patterns and their association with patient outcomes.

bioRxiv · Jun 6, 2026 · PreprintCancer Biology

Tumor cell villages define the co-dependency of tumor and microenvironment in liver cancer

Meng Liu, Maria Olga Hernandez, Darko Castven, Hsin-Pei Lee, Wenqi Wu, Limin Wang, Marshonna Forgues, Jonathan M. Hernandez, Jens Uwe Marquardt, Lichun Ma

The paper uses spatial single-cell data to identify tumor cell clusters (villages) and their microenvironmental dependencies, showing their impact on patient outcomes.

Nature Communications · Feb 21, 2026Peer-reviewedCancer Biology

An ALS-associated TARDBP mutation drives cryptic exon inclusion and RNA dysregulation

Qi Zhang, Meng Liu, Xiaojuan Fan, N.Y. Chin, Yue Xu, Jessica Suh, Soukaina Amniouel, James Virga, Brothely Jones, Kaari L. Linask, Jizhong Zou, Christopher Grunseich, Markus Hafner, Lichun Ma, Yihong Ye, Wei Zheng

Human brain organoids show that a TDP-43 mutation causes RNA mis-splicing and neuronal stress in ALS.

bioRxiv · Nov 9, 2025 · PreprintNeuroscience