Meng Liu

This study defines the spatial architecture of intrahepatic cholangiocarcinoma using single-cell spatial proteomics and a graph-based deep learning framework to identify multicellular spatial patterns and their association with patient outcomes.

The paper uses spatial single-cell data to identify tumor cell clusters (villages) and their microenvironmental dependencies, showing their impact on patient outcomes.

Human brain organoids show that a TDP-43 mutation causes RNA mis-splicing and neuronal stress in ALS.