Mitochondrial dsRNA: A Hidden Source of Immunogenic RNA in ADAR1 Deficiency
Haoqing Shen, Vincent Tano, Jian Han, Vanessa Hui En Ng, Wei Liang Gan, Sze Jing Tang, Ethan Tan, Shu Qin Peng, Larry Ng, Bryan Y.L. Ng, Ka Wai Leong, Xiaohui Sui, Jesslyn Zhou, Leilei Polly Chen
This study identifies mitochondrial dsRNA as a major endogenous dsRNA source in ADAR1 deficiency and proposes a mechanism linking ADAR1 dysfunction to immune activation.
bioRxiv · Jan 7, 2026 · PreprintCell Biology