Author

Sze Jing Tang

National University of SingaporeORCID 0000-0002-4258-6367Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Bryan Y.L. NgiD· 2 shared Haoqing SheniD· 2 shared Jesslyn ZhouiD· 2 shared Jian Han· 2 shared Ka Wai Leong· 2 shared Larry NgiD· 2 shared Leilei CheniD· 2 shared Ömer AniD· 2 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Bryan Y.L. NgORCID

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Author profile →

3 papers

Recent·Most cited

Intron 13 retention expands the ADAR1 isoform repertoire to rewire PKR signaling and promote tumorigenesis

Bryan Y.L. Ng, Jesslyn Zhou, Sze Jing Tang, Yuhua Lim, Vincent Tano, Jovi Jian An Lim, Xi Ren, Ömer An, Jinghe Xie, Jian Han, Haoqing Shen, Larry Ng, Wei Liang Gan, Yangyang Song, Ka Wai Leong, , Peng Chen

The paper identifies novel ADAR1 isoforms generated by intron retention that sequester dsRNA to inhibit PKR and promote tumorigenesis in colorectal cancer.

bioRxiv · May 29, 2026 · PreprintCell Biology

Mitochondrial dsRNA: A Hidden Source of Immunogenic RNA in ADAR1 Deficiency

Haoqing Shen, Vincent Tano, Jian Han, Vanessa Hui En Ng, Wei Liang Gan, Sze Jing Tang, Ethan Tan, Shu Qin Peng, Larry Ng, Bryan Y.L. Ng, Ka Wai Leong, Xiaohui Sui, Jesslyn Zhou, Leilei Polly Chen

This study identifies mitochondrial dsRNA as a major endogenous dsRNA source in ADAR1 deficiency and proposes a mechanism linking ADAR1 dysfunction to immune activation.

bioRxiv · Jan 7, 2026 · PreprintCell Biology

Widespread interaction between ADAR1 and transcriptional byproducts

Chan-Shuo Wu, Sze Jing Tang, Hong Kee Tan, Li-Yuan Hung, Wei Wen Teo, Jia Li, Ömer An, Kar Tong Tan, Qiling Zhou, Leilei Chen, Daniel Geoffrey Tenen, Henry He Yang

This study identifies ADAR1's interaction with transcriptional byproducts using integrated sequencing data, revealing its role in RNA processing and debris clearance.

bioRxiv · Dec 13, 2019 · PreprintGenomics