Vincent Tano

Intron 13 retention expands the ADAR1 isoform repertoire to rewire PKR signaling and promote tumorigenesis

The paper identifies novel ADAR1 isoforms generated by intron retention that sequester dsRNA to inhibit PKR and promote tumorigenesis in colorectal cancer.

Mitochondrial dsRNA: A Hidden Source of Immunogenic RNA in ADAR1 Deficiency

This study identifies mitochondrial dsRNA as a major endogenous dsRNA source in ADAR1 deficiency and proposes a mechanism linking ADAR1 dysfunction to immune activation.

PRMT5 is required for full-length HTT expression by repressing multiple proximal intronic polyadenylation sites

This paper identifies PRMT5 as a regulator of HTT mRNA splicing and alternative polyadenylation, showing that its inhibition reduces full-length HTT protein levels by promoting premature termination and cleavage.

Widespread dysregulation of mRNA splicing implicates RNA processing in the development and progression of Huntington's disease

This study identifies splicing dysregulation in RNA processing and neuronal function genes in early and late-stage Huntington's disease using an isogenic neuronal cell model and post-mortem data.