Author

Eugene S. Chao

Baylor College of Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Joo Hyun KimiD· 3 shared Mingshan XueiD· 3 shared Wu CheniD· 3 shared Allen KuncheriaiD· 1 shared Armand SorianoiD· 1 shared Armando M RiveraiD· 1 shared Arthur L. BeaudetiD· 1 shared Colleen M LongleyiD· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersNeuroscience

Joo Hyun KimORCID

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3 papers

Recent·Most cited

Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome

Dongwon Lee, Wu Chen, Heet Naresh Kaku, Xinming Zhuo, Eugene S. Chao, Armand Soriano, Allen Kuncheria, Stephanie Flores, Joo Hyun Kim, Armando M Rivera, Frank Rigo, Paymaan Jafar‐Nejad, Arthur L. Beaudet, Matthew S. Caudill, Mingshan Xue

This study shows that reducing Ube3a-ATS with antisense oligonucleotides rescues EEG rhythms and sleep in Angelman syndrome mouse models, suggesting a broader therapeutic window than previously believed.

eLife · Jan 3, 2023Peer-reviewedNeuroscience

Glutamatergic and GABAergic neurons mediate distinct neurodevelopmental phenotypes of STXBP1 encephalopathy

Joo Hyun Kim, Wu Chen, Eugene S. Chao, Hongmei Chen, Mingshan Xue

This study shows that glutamatergic and GABAergic neurons mediate distinct disease features in STXBP1 encephalopathy, with GABAergic dysfunction being a main disease mechanism.

bioRxiv · Jul 13, 2021 · PreprintNeuroscience

Stxbp1/Munc18-1 haploinsufficiency in mice recapitulates key features of STXBP1 encephalopathy and impairs cortical inhibition

Wu Chen, Zhao‐Lin Cai, Eugene S. Chao, Hongmei Chen, Colleen M Longley, Shuang Hao, Hsiao‐Tuan Chao, Joo Hyun Kim, Jessica E. Messier, Huda Yahya Zoghbi, Jianrong Tang, John W. Swann, Mingshan Xue

This study shows that Stxbp1 haploinsufficiency in mice causes cognitive, psychiatric, and motor impairments and cortical hyperexcitability, similar to STXBP1 encephalopathy in humans.

eLife · Feb 19, 2020Peer-reviewedNeuroscience