Mingshan Xue

The paper shows developing cortical neurons achieve activity setpoints through input-selective synaptic remodeling, overcoming perturbations by selectively strengthening excitation and reducing inhibition.

This paper identifies NlCCR, a channelrhodopsin from Nutomonas longa, which enables precise optical control of Ca2+ signaling with improved properties compared to existing tools.

The paper identifies blue-shifted channelrhodopsins from ancyromonads that enable multiplex optogenetics by conducting chloride or cation currents with improved spectral properties.

This study reduces neuronal excitability in monkey prefrontal cortex using Kir2.1 channels and finds decreased excitatory synaptic strength without affecting inhibitory inputs.

This study shows that DDHD2 and STXBP1 interact to generate myristic acid, which is essential for long-term memory formation in mice.

This study shows that reducing Ube3a-ATS with antisense oligonucleotides rescues EEG rhythms and sleep in Angelman syndrome mouse models, suggesting a broader therapeutic window than previously believed.

The paper shows that deleting Neuroligin-2 from specific neurons disrupts synaptic excitation-inhibition balance, causing lethality, while deleting it from both neuron types allows survival.

This study shows that glutamatergic and GABAergic neurons mediate distinct disease features in STXBP1 encephalopathy, with GABAergic dysfunction being a main disease mechanism.

This study identifies AnkR's role in regulating fast-spiking interneuron excitability through perineuronal nets and Kv3.1b K+ channels in mouse and human.

This study shows that Stxbp1 haploinsufficiency in mice causes cognitive, psychiatric, and motor impairments and cortical hyperexcitability, similar to STXBP1 encephalopathy in humans.

The paper shows that light-gated chloride channels can have excitatory effects in presynaptic terminals and introduces a targeting motif to improve their inhibitory function in somatodendritic regions.