Wu Chen

Synaptic input-selective homeostasis safeguards developing cortical neurons toward setpoint activity

The paper shows developing cortical neurons achieve activity setpoints through input-selective synaptic remodeling, overcoming perturbations by selectively strengthening excitation and reducing inhibition.

Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome

This study shows that reducing Ube3a-ATS with antisense oligonucleotides rescues EEG rhythms and sleep in Angelman syndrome mouse models, suggesting a broader therapeutic window than previously believed.

Glutamatergic and GABAergic neurons mediate distinct neurodevelopmental phenotypes of STXBP1 encephalopathy

This study shows that glutamatergic and GABAergic neurons mediate distinct disease features in STXBP1 encephalopathy, with GABAergic dysfunction being a main disease mechanism.

Stxbp1/Munc18-1 haploinsufficiency in mice recapitulates key features of STXBP1 encephalopathy and impairs cortical inhibition

This study shows that Stxbp1 haploinsufficiency in mice causes cognitive, psychiatric, and motor impairments and cortical hyperexcitability, similar to STXBP1 encephalopathy in humans.