Colleen M Longley

The paper shows developing cortical neurons achieve activity setpoints through input-selective synaptic remodeling, overcoming perturbations by selectively strengthening excitation and reducing inhibition.

The paper shows that deleting Neuroligin-2 from specific neurons disrupts synaptic excitation-inhibition balance, causing lethality, while deleting it from both neuron types allows survival.

The paper functionally tests ASD missense variants in Drosophila, finding 38% caused functional alterations and identifying GLRA2 as a cause of neurodevelopmental phenotypes.

This study identifies AnkR's role in regulating fast-spiking interneuron excitability through perineuronal nets and Kv3.1b K+ channels in mouse and human.

This study shows that Stxbp1 haploinsufficiency in mice causes cognitive, psychiatric, and motor impairments and cortical hyperexcitability, similar to STXBP1 encephalopathy in humans.