CHIP protects lysosomes from CLN4 mutant-induced membrane damages
Juhyung Lee, N.Y. Chin, Jizhong Zou, Wan Nur Atiqah binti Mazli, Michal Jarník, Layla F. Saidi, Yue Xu, Eutteum Jeong, Jessica Suh, John Michael Replogle, Michael Emmerson Ward, Juan S. Bonifacino, Wei Zheng, Ling Hao, Yihong Ye
The paper identifies CHIP-mediated microautophagy as a protective mechanism against lysosomal damage caused by CLN4 mutations, showing its therapeutic potential in neurodegenerative diseases.
Nature Cell Biology · Aug 25, 2025Peer-reviewedCell Biology