Author

N.Y. Chin

National Institutes of HealthORCID 0009-0004-6370-730XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:genetic perturbation / CRISPR· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Organism:Drosophila· 1 Approach:experimental assay· 1

Frequent Co-Authors

Jizhong ZouiD· 3 shared Wei ZhengiD· 3 shared Yihong YeiD· 3 shared Jessica SuhiD· 2 shared Brothely Jones· 1 shared Christopher GrunseichiD· 1 shared Eutteum Jeong· 1 shared James Virga· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCell Biology

Jizhong ZouORCID

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3 papers

Recent·Most cited

Cellular modifiers of TDP-43 phase transition and cytoplasmic aggregation

N.Y. Chin, Qi Zhang, Jizhong Zou, Ken Chih-Chien Cheng, Wei Zheng, Yihong Ye

This study identifies cellular factors that modulate TDP-43 phase behavior and shows that nuclear export inhibition reduces its aggregation in a brain organoid model.

eLife · Aug 26, 2026Peer-reviewedCell Biology

An ALS-associated TARDBP mutation drives cryptic exon inclusion and RNA dysregulation

Qi Zhang, Meng Liu, Xiaojuan Fan, N.Y. Chin, Yue Xu, Jessica Suh, Soukaina Amniouel, James Virga, Brothely Jones, Kaari L. Linask, Jizhong Zou, Christopher Grunseich, Markus Hafner, Lichun Ma, Yihong Ye, Wei Zheng

Human brain organoids show that a TDP-43 mutation causes RNA mis-splicing and neuronal stress in ALS.

bioRxiv · Nov 9, 2025 · PreprintNeuroscience

CHIP protects lysosomes from CLN4 mutant-induced membrane damages

Juhyung Lee, N.Y. Chin, Jizhong Zou, Wan Nur Atiqah binti Mazli, Michal Jarník, Layla F. Saidi, Yue Xu, Eutteum Jeong, Jessica Suh, John Michael Replogle, Michael Emmerson Ward, Juan S. Bonifacino, Wei Zheng, Ling Hao, Yihong Ye

The paper identifies CHIP-mediated microautophagy as a protective mechanism against lysosomal damage caused by CLN4 mutations, showing its therapeutic potential in neurodegenerative diseases.

Nature Cell Biology · Aug 25, 2025Peer-reviewedCell Biology