Wei Zheng

This study identifies cellular factors that modulate TDP-43 phase behavior and shows that nuclear export inhibition reduces its aggregation in a brain organoid model.

Human brain organoids show that a TDP-43 mutation causes RNA mis-splicing and neuronal stress in ALS.

The paper identifies CHIP-mediated microautophagy as a protective mechanism against lysosomal damage caused by CLN4 mutations, showing its therapeutic potential in neurodegenerative diseases.

This study uses GWAS and eQTL data to identify genetic effects on PUFA levels in RBCs and plasma, finding shared variants and differences in gene expression impacts.

This study identifies reserpine as a drug candidate that improves photoreceptor survival in retinal ciliopathies by restoring proteostasis and ciliogenesis.

This paper develops potent humanized nanobodies against SARS-CoV-2 spike protein, showing effectiveness against the Alpha variant and providing structural insights into their neutralization mechanism.

The paper develops a graph convolutional network to screen compounds for SARS-CoV-2 entry inhibitors, identifying 16 active compounds from 170,000 virtual candidates.

The paper identifies saracatinib as a potent ALK2 inhibitor effective in preventing heterotopic ossification in FOP models.

This study shows SARS-CoV-2 can infect brain cells and organoids derived from human induced pluripotent stem cells, leading to cell death and inflammation, and suggests using these models to study the virus's effects on the brain.

This study identifies virus- and strain-specific molecular signatures of ZIKV infection in human cortical neural progenitors, showing distinct impacts on DNA replication and apoptosis.