Proton FLASH radiotherapy enhances control of triple-negative breast cancer through STING-IRF3 and CD8+ T-cell immunity
Pierre Loap, Ioannis Paraskevaidis, Cezara Cheptea, Kristianna Kolker, Michele Kim, Jufri Setianegara, Kriti Singh, Iulia Maria Berianu, James Metz, Roger A. Greenberg, Warren B. Bilker, Eva Berlin, Charles‐Antoine Assenmacher, Constantinos Koumenis, Eric S. Diffenderfer, , Ioannis I. Verginadis
This study shows that FLASH proton radiotherapy enhances antitumor immunity and tumor control in triple-negative breast cancer by activating STING-IRF3 pathways and CD8+ T-cell responses.
bioRxiv · Sep 22, 2026 · PreprintCancer Biology