Roger A. Greenberg

This study shows that FLASH proton radiotherapy enhances antitumor immunity and tumor control in triple-negative breast cancer by activating STING-IRF3 pathways and CD8+ T-cell responses.

The paper investigates how the BRCA1-A complex recognizes and cleaves K63-linked polyubiquitin chains, revealing structural and functional mechanisms involved in DNA damage response.

The paper shows BRCA1-A complex restricts replication fork reversal in ATM-deficient cells, leading to hypersensitivity to Topoisomerase I inhibitors and resistance to PARP1 inhibitors.

The paper identifies immunogenic endogenous dsRNAs by isolating MDA5 filaments and shows their suppression by ADAR1 and DDX3X.

The paper shows that rDNA breaks generate sense-antisense rRNA transcripts that activate immune signaling via MDA5 and RIG-I.

The paper identifies reversion mutations in homologous recombination genes across cancers, showing they restore DNA repair and confer PARP inhibitor resistance through specific structural alterations.

This study identifies the CHAMP1 complex as a regulator of heterochromatin assembly and replication fork stability, showing its role in preventing genomic instability in cancer cells.

This study shows 53BP1 condensates drive NHEJ foci formation and function as bioreactors and insulators to enhance DNA repair and pathway selection.

The paper identifies first-in-class inhibitors (BLUEs) that selectively inhibit BRISC complex activity by stabilizing an autoinhibited dimer, reducing interferon-stimulated gene expression.

This study identifies the CHAMP1 complex's role in heterochromatin assembly and its enhancement of homology-directed DNA repair in specific genomic regions.

This study identifies inflammatory memory as a mechanism for cancer resistance to immunotherapy and shows that combining JAK and TBK1 inhibitors can prevent it.