Native metabolomics identifies pteridines as CutA ligands and modulators of copper binding
Berenike C. Wagner, Karoline Steuer-Lodd, Christian Geibel, Amelie Stadelmann, Johanna Rapp, Hannes Link, Tilman Schramm, Nouneh Boodaghian, Ansel Hsiao, Eva Nußbaum, Heinz-Paul Grenzendorfer, Reinhard Albrecht, Marcus D. Hartmann, Karl Forchhammer, Khaled A. Selim, , Daniel Petras
The paper identifies pteridines, including lumazine dehydroxyxanthopterin B2, as natural ligands of CutA that modulate copper binding and redox homeostasis in E. coli and Synechococcus elongatus.
Proceedings of the National Academy of Sciences · Nov 25, 2025Peer-reviewedMicrobiology