Chambers C. Hughes

The paper introduces a collaborative platform for curating microbial metabolite knowledge to enhance metabolomics data interpretation.

The paper identifies pteridines, including lumazine dehydroxyxanthopterin B2, as natural ligands of CutA that modulate copper binding and redox homeostasis in E. coli and Synechococcus elongatus.

This study identifies and characterizes the negamycin biosynthetic gene cluster in Kitasatospora purpeofusca, enabling scalable production through heterologous expression.

The paper investigates microbe-microbe interactions in a synthetic microbial community on Arabidopsis leaves, finding that in vitro pairwise interactions differ from in planta correlation networks, suggesting community-level synergism over competition.

This study uses native metabolomics to identify a family of protease inhibitors from cyanobacteria, revealing their structure and potent biological activity.