Hannes Link

The paper investigates how gut commensal strains modulate the growth and virulence of Clostridium perfringens through substrate competition and protein level changes.

This paper develops a continuous bioreactor to maintain stable nasal microbiomes from swab specimens and synthetic communities, showing long-term stability and S. aureus decolonization.

The paper constructs synthetic nasal communities to study how community composition influences metabolic competition and S. aureus colonization resistance.

This study investigates the metabolic and physiological effects of L-lysine on Synechocystis sp. PCC 6803, identifying key genes involved in Lys resistance and metabolic disruption.

The paper identifies pteridines, including lumazine dehydroxyxanthopterin B2, as natural ligands of CutA that modulate copper binding and redox homeostasis in E. coli and Synechococcus elongatus.

The paper investigates how dietary components and Enterobacteriaceae influence competition between Prevotellaceae and Bacteroidaceae in the gut microbiota, finding that Enterobacteriaceae enhance Prevotellaceae dominance under specific conditions.

The paper shows that tyrosine availability influences Staphylococcus aureus nasal colonization and its interactions with commensal bacteria.

This study identifies the HflK-HflC complex as essential for aerobic respiration in E. coli by regulating IspG abundance and ubiquinone levels.

This paper introduces a method to simultaneously detect CRISPRi strain barcodes and metabolites using FI-MS, revealing pathway-specific metabolic changes in engineered bacteria.

This study identifies three genetic mutations enabling E. coli to grow autotrophically when combined with non-native enzymes for carbon fixation and energy production.

The paper constructs a CRISPR library of E. coli mutants to identify temperature-sensitive mutants and demonstrates their use in engineering bacterial metabolite production.