Enhancement of mediodorsal thalamus rescues aberrant belief dynamics in a mouse model with schizophrenia-associated mutation.
Tingting Zhou, Yi-Yun Ho, Ray X. Lee, Amanda B Fath, Kathleen He, Jonathan Scott, Navdeep Bajwa, Nolan D. Hartley, Jonathan J. Wilde, Xian Gao, Li Cui, Evan Hong, Matthew R. Nassar, Ralf D. Wimmer, Tarjinder Singh, , Guoping Feng
This study identifies the mediodorsal thalamus as critical for belief dynamics in a schizophrenia mouse model and shows that enhancing its activity rescues cognitive deficits.
bioRxiv · Jan 8, 2024 · PreprintNeuroscience