Jonathan J. Wilde

This study examines Gria3 mutant mice to identify transcriptomic and proteomic changes linked to schizophrenia, finding region-specific gene dysregulation and synaptic protein alterations.

This study identifies the mediodorsal thalamus as critical for belief dynamics in a schizophrenia mouse model and shows that enhancing its activity rescues cognitive deficits.

In mouse zygotes, prime editing installed 10 modifications across 6 genes, but undesired products such as large deletions outnumbered intended edits, traced to PE3 double-nicking.

This study demonstrates that RAD51 enhances interhomolog repair in zygotes, enabling efficient homozygous knock-in without exogenous templates.