Brain-region-specific changes and dysregulation of activity regulated genes in Gria3 mutant mice, a genetic animal model of schizophrenia
Wei-Chao Huang, Ryan J. Kast, Kira A. Perzel Mandell, Borislav Dejanovic, Kevin Bonanno, Sameer Aryal, Zohreh Farsi, Jonathan J. Wilde, Dongqing Wang, Xian Gao, Hasmik Keshishian, Steven A. Carr, Guoping Feng, Morgan Sheng
This study examines Gria3 mutant mice to identify transcriptomic and proteomic changes linked to schizophrenia, finding region-specific gene dysregulation and synaptic protein alterations.
bioRxiv · Nov 15, 2024 · PreprintNeuroscience