Photochemical modification of two fluorene-based molecules yields structurally distinct DNA intercalators with potent anti-MRSA activity
Avery Gaudreau, Matthew D. Beckner, Vincent Du, Ronald S. Flannagan, Varsha Balaji, Evan Papalambropoulos, Chenfangfei Shen, Omar M. El-Halfawy, Elizabeth R. Gillies, David E. Heinrichs
This study identifies fluorene-based DNA intercalators that show potent anti-MRSA activity and anti-virulence effects through photochemical modification.
bioRxiv · Aug 22, 2025 · PreprintMicrobiology