Omar M. El-Halfawy

Clinically-relevant altered antibiotic responses and mechanisms of β-lactam sensitization of MRSA in cystic fibrosis artificial sputum

This study compares antibiotic susceptibility of MRSA in CF sputum-mimetic media to standard MHB, revealing significant discordances and β-lactam sensitization.

Uncovering the mechanisms of clinically-relevant altered antibiotic responses of Staphylococcus aureus under wound infection-mimetic conditions

This study compares antibiotic susceptibility of MRSA in simulated wound fluid and standard broth, revealing significant differences in resistance and sensitization that correlate with in vivo infection results.

Photochemical modification of two fluorene-based molecules yields structurally distinct DNA intercalators with potent anti-MRSA activity

This study identifies fluorene-based DNA intercalators that show potent anti-MRSA activity and anti-virulence effects through photochemical modification.

The antimicrobial potential of traditional remedies of Indigenous Peoples from Canada against MRSA planktonic and biofilm bacteria in wound-infection mimetic conditions

This study evaluates the antimicrobial potential of 85 traditional Indigenous plant extracts against MRSA under wound-infection mimetic conditions, identifying several with growth inhibition and biofilm disruption properties.

Discovery of broad-spectrum bacterial polyamine detoxification inhibitors as potential antivirulence agents and antibiotic adjuvants