Single molecule fingerprinting reveals different growth mechanisms in seed amplification assays for different polymorphs of alpha Synuclein fibrils.
Derrick Lau, Yuan Tang, Vijaya B. Kenche, Thomas Copie, Daryan Kempe, Eve Jary, Noah J. Graves, Maté Biro, Colin Louis Masters, Nicolas L. Dzamko, Yann Gambin, Emma Sierecki
The paper uses single molecule techniques to show that different alpha-synuclein polymorphs have distinct growth mechanisms in seed amplification assays, with one polymorph showing increased secondary nucleation.
ACS Chemical Neuroscience · Aug 28, 2024Peer-reviewedNeuroscience