Derrick Lau

The paper uses single molecule techniques to show that different alpha-synuclein polymorphs have distinct growth mechanisms in seed amplification assays, with one polymorph showing increased secondary nucleation.

The paper uses single molecule spectroscopy to compare the seeding properties of α-synuclein oligomers and preformed fibrils in amplification assays, finding that fibrils dominate the response despite lower quantities.

The paper identifies a two-factor authentication mechanism used by the innate immune system to detect low-abundance HIV-1 DNA through PQBP1-mediated capsid recognition and cGAS recruitment.