Progressive neurodegeneration of the locus coeruleus drives rapid eye movement sleep fragmentation
Noam Zelinger, Noa Regev, Evyatar Burian, Uddi Kimchy, Noam Gabay, Yuval Nir
This study uses Casp3-mediated LC ablation in mice to show that progressive locus coeruleus degeneration causes REM sleep fragmentation and reduced state-dependent calcium activity.
bioRxiv · Oct 16, 2026 · PreprintNeuroscience