Uddi Kimchy

This study uses Casp3-mediated LC ablation in mice to show that progressive locus coeruleus degeneration causes REM sleep fragmentation and reduced state-dependent calcium activity.

This study shows that auditory cortical networks maintain stimulus representations after sensory input ends in both awake and sleeping mice, with different decay patterns in wakefulness and sleep.

This study identifies an early surge of norepinephrine in the pontine reticular nucleus as critical for sensory-evoked awakening, revealing circuit-specific roles of the locus coeruleus.