NeurosciencebioRxivPreprint
Progressive neurodegeneration of the locus coeruleus drives rapid eye movement sleep fragmentation
Noam Zelinger, Noa Regev, Evyatar Burian…·Yuval Nir
This study uses Casp3-mediated LC ablation in mice to show that progressive locus coeruleus degeneration causes REM sleep fragmentation and reduced state-dependent calcium activity.
DOI 10.64898/2026.10.12.758491