Noa Regev

Progressive neurodegeneration of the locus coeruleus drives rapid eye movement sleep fragmentation

This study uses Casp3-mediated LC ablation in mice to show that progressive locus coeruleus degeneration causes REM sleep fragmentation and reduced state-dependent calcium activity.

Auditory network persistence of stimulus representation in awake and naturally sleeping mice

This study shows that auditory cortical networks maintain stimulus representations after sensory input ends in both awake and sleeping mice, with different decay patterns in wakefulness and sleep.

An early surge of norepinephrine along brainstem pathways drives sensory-evoked awakening

This study identifies an early surge of norepinephrine in the pontine reticular nucleus as critical for sensory-evoked awakening, revealing circuit-specific roles of the locus coeruleus.

A bistable inhibitory OptoGPCR for multiplexed optogenetic control of neural circuits

This paper identifies PdCO as a bistable GPCR with high temporal precision for optogenetic control of neural circuits in vivo.

Propofol Anesthesia Concentration Rather Than Abrupt Behavioral Unresponsiveness Linearly Degrades Responses in the Rat Primary Auditory Cortex

This study shows that propofol anesthesia concentration, not abrupt behavioral changes, linearly degrades auditory cortex responses in rats.

Locus-coeruleus norepinephrine activity gates sensory-evoked awakenings from sleep

This study shows that locus-coeruleus norepinephrine activity determines the likelihood of sensory-evoked awakenings from sleep, with reduced activity during sleep suppressing responses to auditory stimuli.

Sleep differentially affects early and late neuronal responses to sounds in auditory and perirhinal cortices

The paper examines how sleep affects neuronal responses to sounds in auditory and perirhinal cortices, finding greater attenuation in perirhinal cortex during NREM and REM sleep.