The Rise and Fall of SARM1 Base-Exchange Inhibitors
Thomas Lundbäck, Vijay Chandrasekar, Chendi Gu, Hyoungseok Ju, Robyn L. McAdam, Maria Palomero, Kasim Sader, Bradley Peter, Lisa Wissler, Philip Nevin, Edmund Foster, Tanguy Jamier, Pravallika Manjappa, Carina A. Johansson, Jenny Sandmark, , Rebecca E. Jarvis
This study identifies and optimizes SARM1 base-exchange inhibitors but finds they paradoxically activate SARM1 at sub-inhibitory concentrations, leading to neurite degeneration and prompting discontinuation of development.
Communications Chemistry · May 19, 2026Peer-reviewedNeuroscience