Hyoungseok Ju

The Rise and Fall of SARM1 Base-Exchange Inhibitors

This study identifies and optimizes SARM1 base-exchange inhibitors but finds they paradoxically activate SARM1 at sub-inhibitory concentrations, leading to neurite degeneration and prompting discontinuation of development.

Reduction of Nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration

This study shows that reducing Nemo-like kinase enhances lysosome biogenesis and improves TDP-43 clearance, alleviating neurodegeneration in mouse models.

Differential effects of Wnt-β-catenin signaling in Purkinje cells and Bergmann glia in SCA1

This study investigates the differential effects of Wnt-β-catenin signaling in Purkinje cells and Bergmann glia in SCA1, showing distinct cellular responses to enhanced signaling in disease models.