Author

Graham Mathew Fraser

AstraZeneca (United Kingdom)ORCID 0000-0002-5733-201XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Andrew Billinton· 1 shared Anette Persson-kry· 1 shared Ayushin Ale· 1 shared Bilada BilicaniD· 1 shared Bradley PeteriD· 1 shared Carina A. JohanssoniD· 1 shared Carina Raynochek· 1 shared Chendi Gu· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperNeuroscience

Andrew Billinton

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3 papers

Recent·Most cited

The Rise and Fall of SARM1 Base-Exchange Inhibitors

Thomas Lundbäck, Vijay Chandrasekar, Chendi Gu, Hyoungseok Ju, Robyn L. McAdam, Maria Palomero, Kasim Sader, Bradley Peter, Lisa Wissler, Philip Nevin, Edmund Foster, Tanguy Jamier, Pravallika Manjappa, Carina A. Johansson, Jenny Sandmark, , Rebecca E. Jarvis

This study identifies and optimizes SARM1 base-exchange inhibitors but finds they paradoxically activate SARM1 at sub-inhibitory concentrations, leading to neurite degeneration and prompting discontinuation of development.

Communications Chemistry · May 19, 2026Peer-reviewedNeuroscience

Proteomic Analysis Links Truncated Tau to Lysosome Motility, Autophagy and Endo-lysosomal Dysfunction

Despoina Goniotaki, Maximilian Hausherr, Steven Lynham, Ayushin Ale, George Chennell, Stefania Marcotti, Katrin Marcus, Wendy J. Noble, Diane P. Hanger, Graham Mathew Fraser, Deepak P. Srivastava

This study examines how Tau35 protein affects lysosomal function and autophagy, identifying early pathological changes linked to neurotoxicity in tauopathies.

Alzheimer s & Dementia · Dec 1, 2025Peer-reviewedNeuroscience

Extracellular monomeric and aggregated tau efficiently enter human neurons through overlapping but distinct pathways

Lewis Evans, Thomas Wassmer, Graham Mathew Fraser, James C. Smith, Michael S. Perkinton, Andrew Billinton, Frederick J. Livesey

The paper investigates how monomeric and aggregated tau enter human neurons through distinct pathways, identifying dynamin- and actin-dependent mechanisms for monomeric tau and dynamin-dependent clathrin-mediated endocytosis for aggregated tau.

Cell Reports · Mar 1, 2018Peer-reviewedNeuroscience