Kasim Sader

This study identifies and optimizes SARM1 base-exchange inhibitors but finds they paradoxically activate SARM1 at sub-inhibitory concentrations, leading to neurite degeneration and prompting discontinuation of development.

This paper introduces a foam film vitrification method for cryo-EM that improves ice thickness control and particle orientation, simplifying specimen preparation.

This study determines the structure of favipiravir-RTP bound to SARS-CoV-2 RdRp, revealing its weak incorporation mechanism and low replication suppression.