Author

F. A. Middleton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

X. J. Chen· 2 shared X. Wang· 2 shared E. de Jong· 1 shared J. Song· 1 shared K. Schneider· 1 shared L. P. Coyne· 1 shared P. T. Massa· 1 shared R. Tawil· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

X. J. Chen

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2 papers

Recent·Most cited

Mitochondrial protein import clogging as a mechanism of disease

L. P. Coyne, X. Wang, J. Song, E. de Jong, K. Schneider, P. T. Massa, F. A. Middleton, T. Becker, X. J. Chen

The paper shows that mutations in mitochondrial preproteins cause clogging of the import pathway, leading to disease by impairing mitochondrial function and cell viability.

bioRxiv · Sep 20, 2022Biochemistry

Cytosolic Adaptation to Mitochondrial Precursor Overaccumulation Stress Induces Progressive Muscle Wasting

X. Wang, F. A. Middleton, R. Tawil, X. J. Chen

ANT1 overexpression causes cytosolic proteostatic stress, leading to muscle atrophy through reduced protein content and anti-mPOS responses.

bioRxiv · Apr 13, 2020 · PreprintCell Biology