Author

E. de Jong

National Institute for Public Health and the Environment

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Biophysics· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Bosco· 1 shared A. Kotecha· 1 shared A. R. Aricescu· 1 shared A. Sente· 1 shared Alewijn Ott· 1 shared Alje Pieter van DamiD· 1 shared Andreas van ArkeliD· 1 shared Angela de HaaniD· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. Bosco

Author profile →

5 papers

Recent·Most cited

Genomic surveillance of multidrug-resistant organisms based on long-read sequencing

Fabian Landman, Casper Jamin, Angela de Haan, Sandra Witteveen, Jeroen Bos, Han G. J. van der Heide, Leo M. Schouls, Antoni P. A. Hendrickx, Dutch CPE/MRSA surveillance study group, Andreas van Arkel, M. A. Leversteijn-van Hall, W. van den den Bijllaardt, Rosa van Mansfeld, Karin van Dijk, B. Zwart, , Radjin Steingrover

This study demonstrates that long-read sequencing is as accurate and more cost-effective than short-read sequencing for molecular characterization of multidrug-resistant organisms.

Genome Medicine · Nov 25, 2024Peer-reviewedGenetic & Genomic Medicine

Mitochondrial protein import clogging as a mechanism of disease

L. P. Coyne, X. Wang, J. Song, E. de Jong, K. Schneider, P. T. Massa, F. A. Middleton, T. Becker, X. J. Chen

The paper shows that mutations in mitochondrial preproteins cause clogging of the import pathway, leading to disease by impairing mitochondrial function and cell viability.

bioRxiv · Sep 20, 2022Biochemistry

Geldanamycin treatment does not result in anti-cancer activity in a preclinical model of orthotopic mesothelioma

M. L. Orozco Morales, C. A. Rinaldi, E. de Jong, S. M. Lansley, Y. C. G. Lee, R. M. Zemek, A. Bosco, R. A. Lake, W. J. Lesterhuis

The paper evaluates geldanamycin's anti-cancer effects in mesothelioma models, finding it inhibits tumor cells in vitro but not in vivo.

bioRxiv · Aug 29, 2022Cancer Biology

PD1+ T-cells correlate with Nerve Fiber Density as a prognostic biomarker in patients with resected perihilar cholangiocarcinoma.

X. Tan, M. Rosin, S. Appinger, J. Bednarsch, D. Liu, G. Wiltberger, J. Garcia Vallejo, S. Jang, Z. Czigany, S. Boroojerdi, N. Gaisa, P. Boor, R. Buelow, J. de Vos-Geelen, L. Valkenburg-van Iersel, , L. Heij

The paper investigates the association between PD1+ T-cells and nerve fiber density (NFD) in resected perihilar cholangiocarcinoma (pCCA) patients, finding that high NFD correlates with improved overall survival.

bioRxiv · Jan 7, 2022 · PreprintCancer Biology

Single-particle cryo-EM at atomic resolution

T. Nakane, A. Kotecha, A. Sente, G. McMullan, S. Masiulis, P. M. G. E. Brown, I. T. Grigoras, L. Malinauskaite, T. Malinauskas, J. Miehling, L. Yu, D. Karia, E. V. Pechnikova, E. de Jong, J. Keizer, , S. Scheres

This paper demonstrates achieving atomic resolution cryo-EM structures for membrane proteins and apo-ferritin using advanced hardware, enabling detailed structural analysis and hydrogen bonding visualization.

Nature · Oct 21, 2020Peer-reviewedBiophysics