H3K36M provokes cellular plasticity to drive aberrant glandular formation and squamous carcinogenesis
E. K. Ko, A. Anderson, J. Zou, S. Huang, S. Cho, F. Alawi, S. Prouty, V. Lee, K. Ge, J. T. Seykora, B. C. Capell
This study shows that H3K36M oncohistone disrupts epithelial differentiation, increases cellular plasticity, and drives squamous carcinogenesis by altering histone modifications.
bioRxiv · Aug 19, 2022 · PreprintCancer Biology