Author

B. C. Capell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 4 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2

Frequent Co-Authors

J. Zou· 4 shared A. Anderson· 2 shared J. T. Seykora· 2 shared K. Ge· 2 shared S. Egolf· 2 shared S. Huang· 2 shared S. Prouty· 2 shared Y. Aubert· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersCell Biology

J. Zou

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Targeting SERCA2 in organotypic epidermis reveals MEK inhibition as a therapeutic strategy for Darier disease.

S. A. A. Zaver, M. K. Sarkar, S. Egolf, J. Zou, A. Tiwaa, B. C. Capell, J. E. Gudjonsson, C. L. Simpson

This study uses human organotypic epidermis to show that SERCA2 deficiency disrupts keratinocyte adhesion via ERK signaling, and identifies MEK inhibition as a potential therapy for Darier disease.

bioRxiv · Mar 7, 2023Cell Biology

Stress vesicles are induced by acute mechanical force and precede the commitment of epidermal stem cells to terminal differentiation

S. Huang, P. Kuri, J. Zou, A. Blanco, M. Marshall, G. Rice, S. Prouty, T. Dentchev, M. Doepner, J. D. Boerckel, B. C. Capell, T. W. Ridky, P. Rompolas

This study shows that mechanical stress induces stress vesicles in epidermal stem cells, which are linked to cell fate and regulated by Piezo1 and calcium dynamics.

bioRxiv · Sep 29, 2022 · PreprintCell Biology

The carnitine shuttle links mitochondrial metabolism to histone acetylation and lipogenesis

L. T. Izzo, S. Trefely, C. Demetriadou, J. Drummond, T. Mizukami, N. Kuprasertkul, A. Farria, P. Nguyen, L. Reich, J. Shaffer, H. Affronti, A. Carrer, A. Andrews, B. C. Capell, N. W. Snyder, K. E. Wellen

This study identifies the carnitine shuttle and CrAT as a pathway for mitochondrial-to-cytosolic acetyl-CoA transfer, independent of ACLY, in cancer cells.

bioRxiv · Sep 24, 2022 · PreprintCell Biology

H3K36M provokes cellular plasticity to drive aberrant glandular formation and squamous carcinogenesis

E. K. Ko, A. Anderson, J. Zou, S. Huang, S. Cho, F. Alawi, S. Prouty, V. Lee, K. Ge, J. T. Seykora, B. C. Capell

This study shows that H3K36M oncohistone disrupts epithelial differentiation, increases cellular plasticity, and drives squamous carcinogenesis by altering histone modifications.

bioRxiv · Aug 19, 2022 · PreprintCancer Biology

MLL4 is a critical mediator of differentiation and ferroptosis in the epidermis

S. Egolf, J. Zou, A. Anderson, Y. Aubert, K. Ge, J. T. Seykora, B. C. Capell

This study identifies MLL4's role in promoting epidermal differentiation and ferroptosis, linking it to tumor suppression and skin homeostasis.

bioRxiv · May 3, 2021 · PreprintCancer Biology

Differential gene expression by RNA-Seq in Sigma-2 Receptor/TMEM97 knockout cells reveals its role in complement activation and SARS-CoV-2 viral uptake

A. Riad, Y. Aubert, C. Zeng, T. J. A. Graham, E. J. Petersson, B. C. Capell, R. H. Mach

This study uses RNA-Seq to identify differentially expressed genes in sigma-2R/TMEM97 knockout cells, revealing its role in complement activation and SARS-CoV-2 viral uptake.

bioRxiv · Mar 14, 2021 · PreprintCell Biology