Author

F. Ambrosio

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cell Biology· 1 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:statistical model· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:scRNA-seq· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:diffusion model· 1

Frequent Co-Authors

H. Iijima· 3 shared A. Sahu· 2 shared G. Gilmer· 2 shared H. Mamiya· 2 shared S. Sivakumar· 2 shared A. Barchowsky· 1 shared A. C. Bean· 1 shared A. D'Amore· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersPathology

H. Iijima

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A network medicine approach to elucidate mechanisms underlying menopause-induced knee osteoarthritis

G. Gilmer, H. Iijima, N. Jackson, Z. Hettinger, A. C. Bean, J. Bergmann, C. Evans, R. C. Thurston, F. Ambrosio

This study identifies menopause-induced cartilage degradation, senescence, and extracellular matrix disassembly, and suggests hormone therapy or senolytics may mitigate these effects.

bioRxiv · Mar 2, 2023 · PreprintPathology

Dynamical modeling reveals RNA decay mediates the effect of matrix stiffness on aged muscle stem cell fate

Z. R. Hettinger, S. Hu, H. Mamiya, A. Sahu, H. Iijima, K. Wang, G. Gilmer, A. Miller, G. Nasello, A. D'Amore, D. A. Vorp, T. A. Rando, J. Xing, F. Ambrosio

This study shows that matrix stiffness affects aged muscle stem cell self-renewal through RNA decay dynamics, which can be modulated by young matrix environments.

bioRxiv · Feb 24, 2023 · PreprintCell Biology

The fidelity of genetic information transfer with aging skeletal muscle segregates according to biological processes

S. Sivakumar, R. LeFebre, G. Menichetti, H. IIjima, A. Mugler, F. Ambrosio

The paper quantifies age-related decline in transcription factor-target gene communication efficiency using single-cell RNA-seq data from skeletal muscle.

bioRxiv · Jul 18, 2022 · PreprintBioengineering

The biphasic and age-dependent impact of Klotho on hallmarks of aging and skeletal muscle function

A. Pius, Z. Clemens, S. Sivakumar, A. Sahu, S. Shinde, H. Mamiya, N. Luketich, J. Cui, J. Hoeck, S. Kreuz, M. Franti, A. Barchowsky, F. Ambrosio

This study uses a statistical physics approach to assess aging-related entropy in skeletal muscle and shows that Klotho overexpression improves muscle function in older mice but not beyond a certain age threshold.

bioRxiv · Jul 22, 2020Physiology