Author

T. A. Rando

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5

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Research Focus:cell type annotation· 4 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2

Frequent Co-Authors

A. Colville· 2 shared J. D. D. Klein· 2 shared A. Brunet· 1 shared A. d. Morree· 1 shared A. D'Amore· 1 shared A. Goshayeshi· 1 shared A. Lieu· 1 shared A. Miller· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersCell Biology

A. Colville

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Author profile →

5 papers

Recent·Most cited

Dynamical modeling reveals RNA decay mediates the effect of matrix stiffness on aged muscle stem cell fate

Z. R. Hettinger, S. Hu, H. Mamiya, A. Sahu, H. Iijima, K. Wang, G. Gilmer, A. Miller, G. Nasello, A. D'Amore, D. A. Vorp, T. A. Rando, J. Xing, F. Ambrosio

This study shows that matrix stiffness affects aged muscle stem cell self-renewal through RNA decay dynamics, which can be modulated by young matrix environments.

bioRxiv · Feb 24, 2023 · PreprintCell Biology

Death-seq identifies regulators of cell death and senolytic therapies

A. Colville, J.-Y. Liu, S. Thomas, H. D. Ishak, R. Zhou, J. D. D. Klein, D. W. Morgens, A. Goshayeshi, J. S. Salvi, D. Yao, K. Spees, M. C. Bassik, T. A. Rando

Death-seq identifies enhancers of cell death and senolytic therapies through a CRISPR screen, revealing synergistic combinations that clear senescent cells without thrombocytopenia.

bioRxiv · Apr 1, 2022Cell Biology

Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging

L. Liu, S. Kim, M. T. Buckley, J. M. Reyes, J. Kang, L. Tian, T. Wang, A. Lieu, M. Mao, C. Mateo-Rodriguez, H. Ishak, M. Jeong, J. C. Wu, M. A. Goodell, A. Brunet, T. A. Rando

This study examines how exercise affects stem cell compartments and immune cells in aging mice, identifying rejuvenating effects and transcriptomic changes.

bioRxiv · Jan 12, 2022Cell Biology

Fasting Induces a Highly Resilient Deep Quiescent State in Muscle Stem Cells via Ketone Body Signaling

D. I. Benjamin, P. I. Both, J. S. Benjamin, C. W. Nutter, J. H. Tan, J. I. Kang, L. A. Machado, J. D. D. Klein, A. d. Morree, S. I. Kim, L. I. Liu, H. Dulay, L. Feraboli, S. M. Louie, D. K. Nomura, T. A. Rando

This study shows that fasting induces a deep quiescent state in muscle stem cells through ketone body signaling, enhancing their resilience to stress.

bioRxiv · Jan 4, 2022Cell Biology

Transient non-integrative nuclear reprogramming promotes multifaceted reversal of aging in human cells

T. J. Sarkar, M. Quarta, S. Mukherjee, A. Colville, P. Paine, L. Doan, C. M. Tran, C. R. Chu, S. Horvath, N. Bhutani, T. A. Rando, V. Sebastiano

This study shows that transient non-integrative nuclear reprogramming reverses aging in human cells by rejuvenating epigenetic clocks and cellular functions without losing identity.

bioRxiv · Mar 18, 2019Cell Biology