S. Shinde

Evidence that metastases arise de novo as new cancers from cells of target organs

The paper shows that metastases form de novo in target organs when chromatin particles from dying cancer cells transform local cells into new cancers.

Cell-free chromatin particles activate immune checkpoints in human T cells: Implications for cancer therapy

The paper shows that cell-free chromatin particles activate multiple immune checkpoints in human T cells, suggesting a new approach for cancer immunotherapy.

Therapeutic interventions on human xenografts promote systemic dissemination of oncogenes

The paper shows that therapeutic interventions in human xenografts increase oncogene dissemination, which can be reduced by chromatin deactivating agents.

Effect of Human Mesenchymal Stem Cells on Freund's adjuvant-induced Rheumatoid Arthritis in Sprague Dawley Rats

This study evaluates the anti-inflammatory effects of human mesenchymal stem cells (MSCs) in Freund's adjuvant-induced arthritis in rats, showing reduced inflammation and cytokine changes across different RA severities.

The biphasic and age-dependent impact of Klotho on hallmarks of aging and skeletal muscle function

This study uses a statistical physics approach to assess aging-related entropy in skeletal muscle and shows that Klotho overexpression improves muscle function in older mice but not beyond a certain age threshold.

Functional imaging of microbial interactions with tree roots using a microfluidics setup

The paper develops a microfluidic device to study root-microbe interactions in aspen trees and finds that bacterial colonization dynamics depend on host-bacterium compatibility.

Antinociceptive and Antioxidant Activities of Methanolic Extract of Leaves of Azadirachta Indica (Neem).

This study evaluates the antinociceptive and antioxidant properties of methanolic extract from Azadirachta indica leaves in mice using various pain and oxidative stress models.

Glycogen metabolism jump-starts photosynthesis through the oxidative pentose phosphate pathway (OPPP) in cyanobacteria

This study shows glycogen metabolism via the oxidative pentose phosphate pathway (OPPP) initiates photosynthesis in cyanobacteria by modulating NADPH levels during dark-light transitions.