S. Hu

Global Marine Cold Seep Metagenomes Reveal Diversity of Taxonomy, Metabolic Function, and Natural Products

The paper analyzes metagenomes from cold seeps to create a database showing microbial diversity and potential natural products.

A smartphone-based genetically recombinant whole-cell biosensor for highly sensitive monitoring of polychlorinated biphenyls (PCBs)

This paper develops a genetically engineered whole-cell biosensor using E. coli to detect multiple PCB congeners with high sensitivity, and integrates it with a smartphone for real-time monitoring.

Structural and functional analysis of the Nipah virus polymerase complex

This study determines the cryo-EM structure of the Nipah virus polymerase complex and identifies key domains critical for replication and transcription.

Therapeutic potential of SOX9 dysruption in Combined Hepatocellular Carcinoma-Cholangiocarcinoma

This study contrasts the effects of developmental and acute Sox9 deletion in cHCC-CCA models, showing that Sox9 elimination can reduce tumor burden and highlights therapeutic potential.

Characterizing interactions of ER resident proteins in situ through the YST-PPI method

The paper introduces YST-PPI, a method to study ER resident protein interactions in situ, identifies 74 protein pairs, and highlights Lhs1p's role in regulating these interactions.

Fundamental transport mechanism of mucin-2 ER-to-Golgi trafficking identifies source of ER stress in inflammatory bowel disease

The paper identifies that impaired COPII vesicle enlargement due to reduced TANGO1 expression contributes to ER stress in IBD by affecting mucin-2 secretion.

Aquaporins enriched in endothelial vacuole membrane regulate the diameters of microvasculature in hyperglycemia

This study identifies aquaporins in endothelial cells that regulate microvascular diameter in hyperglycemia, suggesting they are potential targets for diabetes-related vascular therapy.

Jumbo phages possess independent synthesis and utilization systems of NAD+

This study identifies NAD-jumbo phages, which synthesize and utilize NAD+ for their life cycle, and finds they are widespread in various ecosystems.

The Transcription Factor OsNAC5 Mediates Cadmium Stress Response and Accumulation in Rice

This study identifies OsNAC5 as a transcription factor that regulates Cd uptake in rice by activating OsNRAMP1, reducing Cd accumulation in grains.

Deletion of Nrf1 exacerbates oxidative stress-induced cellular senescence by disrupting the cell homeostasis

This study shows that deleting Nrf1 increases oxidative stress-induced cellular senescence by disrupting homeostasis, as evidenced by increased senescence markers and impaired autophagy.

Structural basis of Ebola virus nucleocapsid assembly and functions

This study determines the structure of the Ebola virus nucleocapsid using cryo-EM and identifies VP24's role in assembly and function.

SlWRKY80 recruits SlHDA1 to regulates the tomato fruit ripening and color transformation

This study identifies SlWRKY80's role in tomato fruit ripening and color change by regulating SlSGR1 and SlPSY1 through recruitment of SlHDA1.

The transcription factor OsbZIP48 governs rice responses to zinc deficiency

This study identifies OsbZIP48 as a transcription factor critical for rice's response to zinc deficiency, showing it regulates zinc transporter genes through direct promoter binding.

Target-aware Molecule Generation for Drug Design Using a Chemical Language Model

This paper introduces TamGen, a chemical language model for target-aware molecule generation, and shows it produces high-quality compounds with inhibitory activity against Tuberculosis ClpP protease.

Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction

This study shows capsaicin directly binds KEAP1 and allosterically activates NRF2, reducing ethanol-induced gastric oxidative damage and suggesting its potential as a novel NRF2 agonist for oxidative stress-related diseases.

Not dasycladalean alga, but an Odyssey of the earliest Phanerozoic animal reef-builders

The paper reclassifies Protomelission? sp. as archaeocyath-like sponges, challenging previous interpretations and providing insights into early animal reef-building.

Metabolic interactions of a minimal bacterial consortium drive robust nitritation at acidic pH

This study identifies a minimal bacterial consortium that efficiently drives nitritation at acidic pH through metabolic interactions and stress adaptation mechanisms.

Climate warming suppresses soil abundant fungal taxa and reduces soil carbon efflux in a semi-arid grassland

This study shows that warming reduces fungal abundance and shifts fungal community composition in semi-arid grasslands, leading to reduced soil carbon efflux.

Proximal immune-epithelial progenitor interactions drive chronic tissue sequelae post COVID-19

This study identifies dysregulated immune-epithelial progenitor interactions in post-viral lung sequelae and shows that targeting IFN-γ, TNF, or IL-1β improves alveolar regeneration and pulmonary function.

Distinct mechanisms by which antioxidant transcription factors Nrf1 and Nrf2 as drug targets contribute to the anticancer efficacy of Cisplatin on hepatoma cells

This study investigates how antioxidant transcription factors Nrf1 and Nrf2 influence the anticancer effect of Cisplatin on hepatoma cells through distinct molecular mechanisms.

Recombinant Rotavirus Expressing the Glycosylated S1 Protein of SARS-CoV-2

This study generates recombinant rotaviruses expressing full-length, glycosylated SARS-CoV-2 S1 protein, showing they can bind ACE2 and be recognized by anti-S1 antibodies.

Sorcin-STAT3-Serpin E1/CCL5 axis can be the trigger of pancreatic cancer-associated new-onset diabetes

This study identifies a Sorcin-STAT3-Serpin E1/CCL5 signaling axis that drives pancreatic cancer-associated new-onset diabetes by impairing beta-cells and elevating serpin E1 levels in peripheral blood.

Huntingtin loss in hepatocytes is associated with altered metabolism, adhesion, and liver zonation

This study shows that reducing huntingtin in liver cells leads to metabolic changes, altered cell adhesion, and disrupted liver zonation patterns in mice.

Optimizing Cell Therapy by Sorting Cells with High Extracellular Vesicle Secretion

The paper develops a method to enrich cells with high extracellular vesicle secretion and shows improved therapeutic outcomes in a mouse model.

Stanniocalcin 2 (STC2) is a potent biomarker of hepatocellular carcinoma with its expression being augmented in Nrf1α-deficient cells, but diminished in Nrf2-deficient cells

The paper identifies STC2 as a biomarker for hepatocellular carcinoma, showing its expression is increased in Nrf1α-deficient cells and decreased in Nrf2-deficient cells, with STC2 promoting tumor growth.

Stricturing Crohn's disease single-cell RNA sequencing reveals fibroblast heterogeneity and intercellular interactions

This study uses single-cell RNA sequencing to analyze fibroblast heterogeneity and interactions in Crohn's disease strictures, identifying CDH11 as a potential therapeutic target.

Temporal colonization of the gut microbiome in neonatal Bos taurus at single nucleotide resolution

This study tracks microbial colonization in neonatal calves and identifies genetic links between microbes and host metabolites affecting health and growth.

Early microbial intervention reduces diarrhea while improves later milk production in newborn calves

This study shows that early microbial intervention in newborn calves reduces diarrhea and improves later milk production by altering gut microbiome composition and metabolite profiles.

Degenerated CRISPRs widely regulate Cas expression to balance immunity and cost

The paper shows degenerated CRISPRs encode regulatory RNAs that autoregulate Cas protein expression, balancing immunity and host fitness costs.

Dynamical modeling reveals RNA decay mediates the effect of matrix stiffness on aged muscle stem cell fate

This study shows that matrix stiffness affects aged muscle stem cell self-renewal through RNA decay dynamics, which can be modulated by young matrix environments.